When I got home two days ago, my 23 year-old son had borrowed my Manduka yoga mat. And he used it upside down. Seriously? "Dude, you used the mat upside down." "Really? It worked great!" That wasn't how the mat was "supposed" to work, but it did. That's the cool thing about Manduka yoga mats: any way you use them, they work.
We wouldn't recommend using anything incorrectly, least of all a yoga mat, but you can at least have the peace of mind knowing that if you do accidentally use the mat upside down, you're still not going to slip or lose your grip. However, the right side is actually the best for traction and grip. Manduka yoga mats are designed with a unique texture that allows for extra surface area for hands and feet to grip. Slide your hands across one and see.
Manduka yoga mats, whether you choose the Pro version or Pro Lite, have a closed-cell surface that won't allow moisture and sweat to seep into the mat and breed bacteria. If you're into hot yoga or like to take your yoga mat onto the beach to enjoy your practice in the sunshine, the Manduka mats are a great choice. Their surface will not flake off or peel away because the designers chose a sustainable method of manufacturing that prevents this. In fact, the more you use your mat, the better it gets.
You can use your Manduka yoga mat any way you like; at a studio, at home, on the beach; in a house, with a mouse, here or there, you can use them anywhere! And if it happens to get used upside down, well, no need to worry. Flip it over and brush it off. You'll be fine. I was!